Research on CBD, THC, and other cannabinoids:

1.  J Am Pharm Assoc (2003) . Jan-Feb 2020;60(1):253-261. doi: 10.1016/j.japh.2019.11.008. Epub 2019 Dec 19. Use of cannabidiol in anxiety and anxiety-related disorders Jessica W Skelley, Crystal M Deas, Zachary Curren, Jonathan Ennis PMID: 31866386 DOI: 10.1016/j.japh.2019.11.008

2. Curr Pain Headache Rep . 2020 Jan 24;24(2):4. doi: 10.1007/s11916-020-0835-4. The Role of Cannabidiol (CBD) in Chronic Pain Management: An Assessment of Current Evidence Shafik Boyaji 1 2, Justin Merkow 1 2, R Noel M Elman 3, Alan D Kaye 4, R Jason Yong 1 2, Richard D Urman 5 Affiliations expand PMID: 31980957 DOI: 10.1007/s11916-020-0835-4

1. Milar S, Stone N, YatesA, O’Sullivan S. A systematic review of the pharmacokinetics of cannabidiol in humans. Frontiers in Pharma 26 Nov 2018   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275223/ 

2. Jiang R, Yamaori S, Takeda S, Yamamoto I, Watanabe K. Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes. Life Sciences 89 (2011) 165-170  https://pubmed.ncbi.nlm.nih.gov/21704641/ 

3. Zendulka O, Dovrelova G, Noskova K, Turjap M, SulcovaA, Hanus L, Jurica J. Cannabinoids and Cytochrome P450 Interactions. Curr Drug Metab 2016;17(3):206-26   https://pubmed.ncbi.nlm.nih.gov/26651971/ 

4. Rajinder K. Bhardwaj, Hartmut Glaeser, Laurent Becquemont, Ulrich Klotz, Suresh K. Gupta and Martin F. Fromm. Piperine. A Major Constituent of Black Pepper, Inhibits Human P-glycoprotein and CYP3A4. J Pharmacol Exp Ther.August 2002, 302 (2) 645-650   https://pubmed.ncbi.nlm.nih.gov/12130727/

5. Volak L, Ghirmai S, Cashman J, and Court M. Curcuminoids inhibit multiple human cytochromes P450 (CYP), UDP-glucuronosyltransferase (UGT), and sulfotransferase (SULT) enzymes, while piperine is a relatively selective CYP3A4 inhibitor. Drug Metab Dispos. 2008Aug; 36(8): 1594–1605.   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2574793/

6. Ho P C, Saville D J, Coville P F, Wanwimolruk S. Content of CYP3A4 Inhibitors, Naringin, Naringenin and Bergapten in Grapefruit and Grapefruit Juice Products. PharmActa Helv. 2000Apr;74(4):379-85. https://pubmed.ncbi.nlm.nih.gov/10812937/

7. Fasinu P, Choonara Y, Khan R, Du Toit L C, Kumar P, Ndesendo V, Pillay V. Flavonoids and Polymer Derivatives as CYP3A4 Inhibitors for Improved Oral Drug Bioavailability. J Pharm Sci . 2013 Feb;102(2):541-55.   https://www.semanticscholar.org/paper/Flavonoids-and-polymer-derivatives-as-CYP3A4-for-Fasinu-Choonara/f864b48f29cc8abe610cc8f7b6300202ad4d4300

8. Wadhwa S, Singhal S, Rawat S. Bioavailability Enhancement by Piperine: AReview.Asian J Biomed & Pharm Sciences. Vol 4, Issue 36, 2014.   https://www.alliedacademies.org/abstract/bioavailability-enhancement-by-piperine-a-review-5121.html

*These statements have not been evaluated by the FDA. This product is not intended to treat, diagnose, or cure any disease. Consult your personal medical professional before use.

1. https://journals.sagepub.com/doi/abs/10.1177/17151635221089617#.YmGO0n9SUBk.linkedin

2. Δ9-Tetrahydrocannabivarin (THCV): a commentary on potential therapeutic benefit for the management of obesity and diabetes  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7819335/pdf/42238_2020_Article_16.pdf

3. Efficacy and Safety of Cannabidiol and Tetrahydrocannabivarin on Glycemic and Lipid Parameters in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Pilot Study  https://pubmed.ncbi.nlm.nih.gov/27573936/ 

1.  Opiate reduction with cannabis 2017 by Dr. Burchman   https://journals.sagepub.com/doi/abs/10.1177/0269881117699616 

2.  Use of Cannabis to Relieve Pain and Promote Sleep by Customers at an Adult Use Dispensary  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823130/ 

1.  HHC and tumors: https://pubmed.ncbi.nlm.nih.gov/?term=Hexahydrocannabinol+tumor 

2.

1. https://archive.ph/1aq0L

2.

1. https://pubmed.ncbi.nlm.nih.gov/29302228/  

2. https://www.safeaccessnow.org/

3. http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=292